Current Treatment options for FAOD

Supportive care

The current standard of care for LC-FAOD is dietary management

Specific treatments may vary according to the specific LC-FAOD disorder and severity. The common approaches to dietary management may include1

  • A low-fat, high-carbohydrate diet
  • Avoidance of fasting
  • Supplementation with carnitine
  • Supplementation with medium-chain triglyceride (MCT) oil


In addition to dietary management, aggressive treatment of comorbidities is essential. Patients with LC-FAOD often require1-3

  • Early interventions for upper respiratory infections, fever, gastroenteritis, and other illnesses
  • ER visits for the
    • Correction/prevention of hypoglycemia
    • Management of metabolic acidosis, hyperammonemia, acute cardiac decompensation, and rhabdomyolysis
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References: 1. Roe CR, Sweetman L, Roe DS, David F, Bruengraber H. Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride. J Clin Invest. 2002;110(2):259–269. doi:10.1172/JCI200215311. 2. MCAD and other fatty acid oxidation disorders. Illinois Department of Public Health: Genetics and Newborn Screening. Accessed August 17, 2016. 3. Medium chain acyl CoA dehydrogenase deficiency. National Organization for Rare Disorders. Updated 2005. Accessed August 17, 2016.